Recovery of Hearing in Cisplatin-Induced Ototoxicity in the Guinea Pig with Intratympanic Dexamethasone
نویسندگان
چکیده
منابع مشابه
Ototoxicity of intratympanic docusate sodium and mineral oil in the guinea pig.
OBJECTIVES (1) To evaluate the ototoxic potential of docusate sodium and mineral oil and (2) to compare the cerumenolytic properties of these agents to water and a commercially available product. STUDY DESIGN Prospective animal study. SETTING Docusate sodium and mineral oil are being used to dissolve cerumen plugs. Their ototoxicity has never been assessed. METHODS Nineteen guinea pigs re...
متن کاملHydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig
Introduction: Permanent hearing loss and tinnitus as side-effects from treatment with the anticancer drug cisplatin is a clinical problem. Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far been modest. Aim: The present preclinical in vivo study aimed to explore the protective efficacy of hydrogen (H2) inhalation on ototoxicity induc...
متن کاملTargeted amelioration of cisplatin-induced ototoxicity in guinea pigs.
This pilot study compared otoprotection provided by trans-tympanic formulations and systemic intraperitoneal administration of L-N-acetylcysteine from cisplatin-induced cochlear oxidative stress. Protection was assessed by measures of hearing loss and cochlear glutathione levels. All groups received an equivalent single dose of L-N-acetylcysteine followed by cisplatin. Cisplatin was administere...
متن کاملA Revision in Evaluating the Results of Intratympanic Otoprotective Injections against Cisplatin-Induced Ototoxicity.
causing an inability of the epiglottis to retroflex adequately during deglutition. The epiglottis then acted as an impediment to swallowing, instead of moving out of the way of the food bolus. Cervical osteophytes were one cause of pharyngeal crowding. However, pharyngeal crowding was also seen after anterior cervical spine surgery due to an increase in pharyngeal wall thickness. We therefore i...
متن کاملResponse to "A Revision in Evaluating the Results of Intratympanic Otoprotective Injections against Cisplatin-Induced Ototoxicity".
showed significant changes in frequencies >8 kHz that were not detected with the routine pure tone audiometry and distortion product otoacoustic emission audiodiagnostic tests. In conclusion, although the idea of such studies about the otoprotective effect of intratympanic injections against cisplatininduced ototoxicity seems magnificent and deserves more modifications, a careful revision in ev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Otolaryngology and Head & Neck Surgery
سال: 2011
ISSN: 2231-3796,0973-7707
DOI: 10.1007/s12070-011-0160-7